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  • pharmacogenomics: a key component of personalized therapy

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1079
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    the goal of personalized medicine is to provide individualized treatment and to predict the clinical outcome ofdiff erent treatments in diff erent patients. pharmacogenomicsis one of the core elements in personalized medicine. the basic concept is that interindividual variability in drug response is a consequence of multiplefactors, including genomics, epigenomics, the environmentand a patient’s characteristics, such as gender, ageand/or concomitant medication. th irty years ago,drug response was found to be altered by genetic polymorphismsin drug-metabolizing enzymes (for example,the cytochrome p450 2d6 and the thiopurine s-methyltransferase), yet valid and predictive biomarkers fortherapeutic eff ects and/or for avoiding severe side eff ectsare lacking for more than 90% of drugs currently used inclinical practice. pharmacogenomics in recent years hasused a new generation of technologies known as ‘omics’approaches that has led to a revolution in the understanding of disease susceptibility and pathophysiology,providing enormous potential for novel therapeutic strategies.

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