• flexibility of active-site gorge aromatic residues and non-gorge aromatic residues in acetylcholinesterase

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 765
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the presence of an unusually large number of aromatic residues in the active site gorge of acetylcholinesterase is a subject of great interest. flexibility of these residues has been suspected to be a key player in controlling the ligand traversal in the gorge. this raises the question of whether the over-representation of aromatic residues in the gorge implies higher-than-normal flexibility of these residues. the current study suggests that it does not. large changes in the hydrophobic cross-sectional area due to dihedral oscillations are probably the reason of their presence in the gorge.

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