• the divergence and natural selection of autocatalytic primordial metabolic systems

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1109
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    • شماره تماس دبیرخانه رویداد: -
     the diversity of the central metabolism of modern organisms is caused by the existence of a few metabolic modules, combination of which produces multiple metabolic pathways. this paper analyzes biomimetically reconstructed coupled autocatalytic cycles as the basis of ancestral metabolic systems. the mechanism for natural selection and evolution in autocatalytic chemical systems may be affected by natural homeostatic parameters such as ambient chemical potentials, temperature, and pressure. competition between separate parts of an autocatalytic network with positive-plus-negative feedback resulted in the formation of primordial autotrophic, mixotrophic, and heterotrophic metabolic systems. this work examined the last common ancestor of a set of coupled metabolic cycles in a population of protocells. physical-chemical properties of these cycles determined the main principles of natural selection for the ancestral bacteria and archaea taxa.

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