• neuroprotective effect of 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside against sodium nitroprusside-induced neurotoxicity in ht22 cells

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1125
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     2-(4-methoxyphenyl) ethyl-2-acetamido-2-deoxy-β-d-pyranoside (glcnac-sal), the salidroside analog was synthesized and shown to inhibit hypoglycemia and serum limitation induced apoptosis in pc12 cells. this study investigated the protective effects of glcnac-sal on sodium nitroprusside (snp)-induced cytotoxicity in ht22 cells. cell viability tests and hoechst 33342 staining comfirmed that glcnac-sal pretreatment attenuated snp-stimulated apoptotic cell death in ht22 cells in a concentration-dependent manner. the measurements of reactive oxygen species (ros), nitric oxide (no) production and apoptosis-related gene and protein expression suggest that the protection of glcnac-sal, shown in this study, might be mediated by inhibiting intracellular ros and no production, and regulating apoptosis-related gene and protein expression during snp stimulation. perhaps, this study might contribute to the development of glcnac-sal as an agent for preventing and/or treating a variety of no-induced brain diseases.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین ژورنال ها