• mir-141 suppresses proliferation and motility of gastric cancer cells by targeting hdgf

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     mir-141 belongs to the mir-200 family, and has been found to be associated with numerous human malignancies; however, its role in gastric cancer (gc) has not been examined in detail. here, we validated that mir-141 was decreased in gc tissues and cell lines. forced expression of mir-141 significantly repressed gc cell proliferation and colony formation. furthermore, mir-141 suppressed in vitro migration and invasion of gc cells. hepatoma-derived growth factor (hdgf) was confirmed to be a direct target of mir-141 in gc cells. the suppressive effects of mir-141 on gc cell proliferation, colony formation, in vitro migration, and invasion were partially mediated by suppressing hdgf expression. moreover, the expression of hdgf was negatively correlated with mir-141 in gc tissues. our data suggest that mir-141 might be associated and plays essential role in gc progression.

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