• mir-154 suppresses colorectal cancer cell growth and motility by targeting tlr2

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 856
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    • شماره تماس دبیرخانه رویداد: -
     micrornas play critical roles in the development and progression of colorectal cancer (crc). mir-154 acts as a tumor suppressor in several tumors; however, its role in crc is poorly understood. herein, we found that mir-154 was decreased in crc tissues and cell lines. ectopic expression of mir-154 remarkably suppressed cell proliferation and colony formation, migration and invasion in crc cells. the toll-like receptor 2 (tlr2) was found to be a direct target of mir-154 in crc cells. inhibition of tlr2 performed similar effects with mir-154 overexpression on crc cells, and overexpression of tlr2 could significantly reverse the tumor suppressive effects of mir-154 on crc cells. this study suggests an essential role for mir-154 in crc.

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