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میکروسیالات و نانوسیالات 2013
جزئیات رویداد
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  • a microfluidic-based dynamic microarray system with single-layer pneumatic valves for immobilization and selective retrieval of single microbeads

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 873
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    • شماره تماس دبیرخانه رویداد: -
     a simple yet effective dynamic bead-based microarray is necessary for multiplexed high-throughput screening applications in the fields of biology and chemistry. this paper introduces a microfluidic-based dynamic microbead array system using pneumatically driven elastomeric valves integrated with a microchannel in a single polydimethylsiloxane (pdms) layer that performs the following functions: single-microbead arraying with loading and trapping efficiencies of 100 %, sequential microbead release for selective retrieval of microbeads of interest, and rapid microarray resettability (<1 s). the key feature is the utilization of an elastomeric membrane as a valve for trapping and releasing single microbeads; this membrane is deformable depending on the applied pneumatic pressure, thereby simply providing a dual trap-and-release function. we propose an effective single-microbead-trapping mechanism based on a dynamic flow-change network and a mathematical model as the design criterion of a trapping site. a sequential microbead release technique via a multistep “release-retrap-and-repeat” method was developed for the selective retrieval of trapped microbeads with a simple configuration consisting of a single pdms layer and a simple macro-to-micro connection. the proposed dynamic microbead array could be a powerful tool for high-throughput multiplex bead-based drug screening or disease diagnosis.

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