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نویسندگان مقالات پربازدید :
بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • screening of chemopreventive effect of naringenin-loaded nanoparticles in dmba-induced hamster buccal pouch carcinogenesis by ft-ir spectroscopy

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 819
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the aim of the present study is to investigate the chemopreventive effects of the prepared naringenin-loaded nanoparticles (narnps) relative to efficacy of free naringenin (nar) in modifying the functional, structural, and compositional changes at the molecular level during 7, 12-dimethylbenz[a]anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis by fourier transform infrared (ft-ir) spectroscopy. the results revealed that a significant increase in the amount of proteins and nucleic acid contents and a decrease in the amount of lipids and glycogen contents are observed in dmba-induced tumor tissues. in addition, in tumor tissues a decrease in lipid order and a significant increase in membrane dynamics were noticed. further, the composition and secondary structure of proteins were found to be altered, which indicates some important structural alterations in the existing proteins and/or the expression of new types of proteins occurring under the tumor transformation. furthermore, oral administration of free nar and narnps significantly increased lipids and their order as well as increased the glycogen contents and decreased the levels of proteins and nucleic acid contents. on a comparative basis, narnps were found to have a more potent antitumor effect than free nar in completely preventing the formation of squamous cell carcinoma and in improving the biochemical constituents to a normal range in dmba-induced hbp carcinogenesis. the present study further shows a great potential of ft-ir spectroscopy as a complimentary tool for the screening of various anticancer drugs and follow-up, which may allow faster response to critical problems arising during treatment.

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