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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
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همایش ، رویداد ، ژورنال
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  • neuroprotective effects of vitexin by inhibition of nmda receptors in primary cultures of mouse cerebral cortical neurons

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 842
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the accumulation of glutamate can excessively activate the n-methyl-d-aspartate (nmda) receptors and cause excitotoxicity. vitexin (5, 7, 4-trihydroxyflavone-8-glucoside, vit) is a c-glycosylated flavone which was found in the several herbs, exhibiting potent hypotensive, anti-inflammatory, and neuroprotective properties. however, little is known about the neuroprotective effects of vit on glutamate-induced excitotoxicity. in present study, primary cultured cortical neurons were treated with nmda to induce the excitotoxicity. pretreatment with vit significantly prevented nmda-induced neuronal cell loss and reduced the number of apoptotic neurons. vit significantly inhibited the neuronal apoptosis induced by nmda exposure by regulating balance of bcl-2 and bax expression and the cleavages of poly (adp-ribose) polymerase and pro-caspase 3. furthermore, pretreatment of vit reversed the up-regulation of nr2b-containing nmda receptors and the intracellular ca2+overload induced by nmda exposure. the neuroprotective effects of vit are related to inhibiting the activities of nr2b-containing nmda receptors and reducing the calcium influx in cultured cortical neurons.

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