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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic c57bl/6j mice

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 846
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    • شماره تماس دبیرخانه رویداد: -
     thiazolidinediones constitute a family of antidiabetic drugs, and rosiglitasone (rsg) has an extensive usage in treating the complications of type 2 diabetes mellitus. carvacrol (cvl), a monoterpenic phenol that occurs in many essential oils of the family labiatae including origanum, satureja, thymbra, thymus, and corydothymus species, possess a wide variety of pharmacological properties including antioxidant potential. we hypothesized that carvacrol in combination with rsg would prove beneficial to ameliorate the dysregulated carbohydrate metabolism in high-fat diet (hfd)-induced type 2 diabetic c57bl/6j mice. mice were divided into six groups and fed hfd, for 10 weeks. cvl (20 mg/kg bw) and rsg (4 mg/kg bw) were administered post-orally, daily for 35 days. hfd mice showed an elevation in plasma glucose, insulin, glycosylated hemoglobin and a decrease in hemoglobin. the activities of carbohydrate metabolic enzymes such as glucose-6-phosphatase and fructose-1,6-bisphosphatase increased whereas glucokinase and glucose-6-phosphate dehydrogenase activities decreased in the liver of hfd mice. the activities of hepatic marker enzymes such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase increased in hfd mice. combination of cvl and rsg prevented the above changes toward normalcy. histopathological analysis of h&e stained pancreas was also in agreement with the biochemical findings. these major findings provide evidence that combination of cvl with rsg has better antidiabetic properties.

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