• insulin-like growth factor 1 opposes the effects of c-reactive protein on endothelial cell activation

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 934
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     emerging evidence demonstrates that high plasma c-reactive protein (crp) levels or low plasma insulin-like growth factor 1 (igf-1) concentrations may be separately associated with the increased risk of coronary artery disease or myocardial infarction. interestingly, animal model studies and epidemiological investigations indicate that circulating igf-1 and crp levels have an inverse correlation. the present study aims to evaluate if igf-1 can directly oppose the effects of crp on endothelial cell (ec) activation. we found that igf-1 rescues endothelial nitric oxide synthase activity and decreases the release of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 from ecs. we also showed that igf-1 antagonizes the effects of crp by activating the pi3k/akt pathway and suppressing the jnk/c-jun and mapk p38/atf2 signaling pathways, rather than inhibiting erk1/2 activity. these findings provide evidence of the physiopathological mechanisms of endothelial activation and novel insights into the protective properties of igf-1.

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