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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
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  • fibroblast growth factor acts upon the transcription of phospholipase c genes in human umbilical vein endothelial cells

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     besides the control of calcium levels, the phosphoinositide-specific phospholipases c (pi-plcs), the main players in the phosphoinositide signalling pathway, contribute to a number of cell activities. the expression of pi-plcs is strictly tissue specific and evidence suggests that it varies under different conditions, such as tumour progression or cell activation. in previous studies, we obtained a complete panel of expression of pi-plc isoforms in human umbilical vein endothelial cells (huvec), a widely used experimental model for endothelial cells (ec), and demonstrated that the expression of the plc genes varies under inflammatory stimulation. the fibroblast growth factor (fgf) activates the pi-plc γ1 isoform. in the present study, pi-plc expression in fgf-treated huvec was performed using rt-pcr, observed 24 h after stimulation. the expression of selected genes after stimulation was perturbed, suggesting that fgf affects gene transcription in pi signalling as a possible mechanism of regulation of its activity upon the akt-plc pathway. the most efficient effects of fgf were recorded in the 3–6-h interval. to understand the complex events progressing in ec might provide useful insights for potential therapeutic strategies. the opportunity to manipulate the ec might offer a powerful tool of considerable practical and clinical importance.

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