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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
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  • upregulation of microrna-375 is associated with poor prognosis in pediatric acute myeloid leukemia

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     a genome-wide serum mirna expression analysis previously showed the upregulation of microrna-375 (mir-375) in acute myeloid leukemia (aml) patients compared with healthy controls. the aim of this study was to investigate the expression patterns and the prognostic relevance of mir-375 in pediatric aml. expression levels of mir-375 in bone marrow mononuclear cells were detected by real-time quantitative pcr in a cohort of 106 patients with newly diagnosed pediatric aml. expression levels of mir-375 in the bone marrow of pediatric aml patients were significantly higher than those in normal controls (p < 0.001). then, mir-375 upregulation occurred more frequently in french–american–british classification subtype m7 than in other subtypes (p < 0.001). regarding to cytogenetic risk, the expression levels of mir-375 in pediatric aml patients with unfavorable karyotypes were dramatically higher than those in intermediate and favorable groups (p = 0.002). moreover, high mir-375 expression was significantly associated with shorter relapse-free survival (p < 0.001) and overall survival (p < 0.001) in pediatric aml patients. multivariate analysis further identified mir-375 expression and cytogenetics risk as independent prognostic factors for both relapse-free survival and overall survival. in particular, the prognostic relevance of mir-375 expression was more obvious in the subgroup of patients with intermediate-risk cytogenetics. our findings suggest for the first time that the upregulation of mir-375 may be one of the molecular mechanisms involved in the development and progression of pediatric aml. since its correlation with poor relapse-free survival and overall survival, mir-375 may be a novel biomarker to improve the management of pediatric aml patients.

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