potential of raman spectroscopy for evaluating crushing strength of tablets

this study evaluates the sensitivity of raman spectroscopy to changes in physical attributes of the compacted pharmaceutical formulations prepared with lactose monohydrate (49 wt.%), microcrystalline cellulose (49 wt.%), silicone dioxide (1 wt.%), and magnesium stearate (1 wt.%). the tablets made with raw powder were subjected to two iterative dry granulation cycles, i.e., tablet crushing, sieving, and re-tableting. different compaction forces were applied during tableting. small- and wide-angle x-ray scattering was used to study physical changes of the granulates and their respective compacts.