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مجله زیست شناسی اروپای مرکزی 2014
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  • low-dose anisomycin is sufficient to alter the bio-behaviors of jurkat t cells

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     anisomycin is a pyrrolidine antibiotic isolated from streptomyces griseolus. it has been found that a quite low dose of anisomycin is sufficient to block proliferation of primary t lymphocytes. the focus of this study is to explore the possibility of anisomycin to treat human acute leukemia jurkat t cellsin vitro. the results indicated that the low dose of anisomycin could significantly inhibit the colony formation of jurkat t cells and elevate the inhibition rate of jurkat t cell growth along with its increasing concentrations. jurkat t cell cycle was blocked into s-phase by anisomycin. consistent with the increased proportion of sub-g1 phase, anisomycin promoted jurkat t cell apoptosis. the cd69 and cd25 expression on the surface of jurkat t cells was also down-regulated prominently along with the enhancing concentrations of anisomycin, followed by the decreased production of il-4, il-10, il-17, tgf-β and ifn-γ, and the down-regulated expression of phosphorylated-erk1/2. the results suggest that the suppressive effect of anisomycin on jurkat t cell growth may be related to inhibiting tgf-β production and erk1/2 activation, arresting the cell cycle at s-phase and promoting the apoptosis of jurkat t cells.

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