محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
مجله رفتار مکانیکی مواد زیست پزشکی
جزئیات رویداد
همایش ، رویداد ، ژورنال
اینستاگرام تی پی بین

  • incorporation of plga nanoparticles into porous chitosan–gelatin scaffolds: influence on the physical properties and cell behavior

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1394/01/01
    • تاریخ انتشار در تی پی بین: 1394/01/01
    • تعداد بازدید: 1047
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     bone regeneration can be accelerated by localized delivery of appropriate growth factors/biomolecules. localized delivery can be achieved by a 2-level system: (i) incorporation of biomolecules within biodegradable particulate carriers (nanoparticles), and (ii) inclusion of such particulate carriers (nanoparticles) into suitable porous scaffolds. in this study, freeze-dried porous chitosan–gelatin scaffolds (ch–g: 1:2 ratio by weight) were embedded with various amounts of poly(lactide-co-glycolide) (plga) nanoparticles, precisely 16.6%, 33.3% and 66.6% (respect to ch–g weight). scaffolds loaded with plga nanoparticles were subjected to physico-mechanical and biological characterizations including morphological analysis, swelling and dissolution tests, mechanical compression tests and cell viability tests. results showed that incorporation of plga nanoparticles into porous crosslinked ch–g scaffolds: (i) changed the micro-architecture of the scaffolds in terms of mean pore diameter and pore size distribution, (ii) reduced the dissolution degree of the scaffolds, and (iii) increased the compressive modulus. on the other hand, the water uptake behavior of ch–g scaffolds containing plga nanoparticles significantly decreased. the incorporation of plga nanoparticles did not affect the biocompatibility of ch–g scaffolds.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها