محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال
حوزه های تحت پوشش رویداد

  • molecular simulation of flavin adenine dinucleotide immobilized on charged single-walled carbon nanotubes for biosensor applications

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 846
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the reconstitution of apo-glucose oxidase (apo-gox) on single-walled carbon nanotubes (swnts) functionalized with the cofactor, flavin adenine dinucleotide (fad), greatly improved electron transfer turnover rate of the redox reactions in glucose sensing with glucose sensors. the research reported here is aimed to better understand molecular details of affection of the charging swnt to the conformational changes of fad, in order to find a rational design and selection scheme of swnt which is suitable for the fad and apo-gox to perform their reconstitution. in this report, molecular simulations of fad functionalized differently charged swnts were carried outin an aqueous environment, with counterions to maintain total charge neutrality. the conformation and orientation changes were observed by both trajectory and quantitative analyses. the simulation results showed that in both uncharged and positively charged swnt situations, fad adsorbed onto swnt at the end of the simulations, which increased the steric resistance of molecules and hindered the reconstitution of apo-gox and fad to some degree. by contrast, fad functionalized negatively charged swnt maintained its original conformation largely. in addition, negatively charged swnt may be the best choice for electron transfer mediator for the reconstitution of apo-gox on relay-cofactor units associated with electrodes.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها