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  • gd3+ complex-modified naluf4-based upconversion nanophosphors for trimodality imaging of nir-to-nir upconversion luminescence, x-ray computed tomography and magnetic resonance

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 803
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -

    multimodality molecular imaging has recently attracted much attention, because it can take advantage of individual imaging modalities by fusing together information from several molecular imaging techniques. herein, we report a multifunctional lanthanide-based nanoparticle for near-infrared to near-infrared (nir-to-nir) upconversion luminescence (ucl), x-ray computed tomography (ct) and t1-enhanced magnetic resonance (mr) trimodality in-vivo imaging. by careful selection of the lanthanide elements, core–shell structured lanthanide-based nanoparticles, naluf4:yb3+,tm3+@sio2-gddtpa nanoparticles (ucnp@sio2-gddtpa) have been designed and synthesized. we also prove that the application of ucnp@sio2-gddtpa for nir-to-nir ucl, ct and mri multi-modality in-vivo imaging can be established successfully. in addition, the biological toxicity of ucnp@sio2-gddtpa is evaluated by the methyl thiazolyl tetrazolium (mtt) assay and histological analysis of viscera sections.

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