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  • a naybf4: tm3+ nanoprobe for ct and nir-to-nir fluorescent bimodal imaging

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
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     early diagnosis that combines the high-resolutional ct and sensitive nir-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. here we report a simple bimodal imaging platform based on pegylated naybf4: tm3+ nanopaticles (nps) of less than 20 nm in diameter for both ct and nir-fluorescence bioimaging. the as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damge in one month. remarkably, the yb3+ in the lattice of naybf4: tm3+ nps functions not only as a promising ct contrast medium due to its high x-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong nir-fluorescent emissions for its large nir absorption cross-section. in addition, these nps could be easily excreted mainly via feces without detectable remnant in the animal bodies.

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