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نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • micropatterning of mammalian cells on inorganic-based nanosponges

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 636
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     developing artificial scaffolding structures in vitro in order to mimic physiological-relevant situations in vivo is critical in many biological and medical arenas including bone and cartilage generation, biomaterials, small-scale biomedical devices, tissue engineering, as well as the development of nanofabrication methods. we focus on using simple physical principles (photolithography) and chemical techniques (liquid vapor deposition) to build non-cytotoxic scaffolds with a nanometer resolution through using silicon substrates as the backbone. this method merges an optics-based approach with chemical restructuring to modify the surface properties of an ic-compatible material, switching from hydrophilicity to hydrophobicity. through this nanofabrication-based approach that we developed, hydrophobic oxidized silicon nanosponges were obtained. we then probed cellular responses—examining cytoskeletal and morphological changes in living cells through a combination of fluorescence microscopy and scanning electron microscopy—via culturing chinese hamster ovary cells, hig-82 fibroblasts and madin–darby canine kidney cells on these silicon nanosponges. this study has demonstrated the potential applications of using these silicon-based nanopatterns such as influencing cellular behaviors at desired locations with a micro-/nanometer level.

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