محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
اینستاگرام تی پی بین
حوزه های تحت پوشش رویداد

  • enzymatic degradation of heparin-modified hydrogels and its effect on bioactivity

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 644
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the extracellular matrix is continually remodelled by the action of various enzymes such as heparanase, which specifically targets heparan sulfate (hs) and is found in human platelets at high levels. the activity of heparin-containing hydrogels following incubation with platelet extract (pe) was investigated in order to simulate the responses that might occur when the hydrogels, as tissue engineered scaffolds, come in contact with blood products at the site of an injury. the heparanase activity of pe on heparin, used as a model of hs, was confirmed by the decrease in molecular weight. pe treatment diminished heparin's anticoagulation property but increased its fgf-2 signalling activity, suggesting that the pe's heparanase activity cleaves at the 3-o-sulfated glucosamine to produce large fragments that can signal cell receptors. the dual effect observed when poly(vinyl alcohol)/heparin co-hydrogels were incubated with pe supports the hypothesis of platelets having the capacity to limit anticoagulation and thus promote blood clot formation, which may be critical in the process of tissue repair.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها