مقاله Cell response induced by internalized bacterial magnetic nanoparticles under an external static magnetic field : تی پی بین

خلاصه مقاله

Magnetic nanoparticles are widely used in bioapplications such as imaging and targeting tool. Their magnetic nature allows for the more efficient bioapplications by an external field gradient. However their combined effects have not yet been extensively characterized. Herein, we first demonstrate the biological effects of the communications between internalized bacterial magnetic nanoparticles (BMPs) and an external static magnetic field (SMF) on a standard human cell line. Combination of the BMPs and SMF act as the key factor leading to the alteration of cell structure and the enhanced cell growth. Also, their interaction reduced the apoptotic efficiency of human tumor cells induced by anticancer drugs. Microarray analysis suggests that these phenomena were caused by the alterations of GPCRs-mediated signal transduction originated in the interaction of internalized BMPs and the external SMF. Our findings may offer new approach for targeted cell therapy with the advantage of controlling cell viability by magnetic stimulation.

نویسندگان

Jaeha Shin [ School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, South Korea ]

Chang-Hyuk Yoo [ Division of WCU Multiscale Mechanical Design, School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, South Korea ]

Junghoon Lee [ School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, South Korea ]

Misun Cha [ Inter-university Semiconductor Research Center, Seoul National University, Seoul, 151-744, South Korea ]

کلمات کلیدی

Bacterial magnetic nanoparticles (BMPs) Magnetic field Proliferation Antiapoptosis Microarray

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Biomaterials

Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice.

حوزه های تحت پوشش : biomaterials