• designing multilayered particulate systems for tunable drug release profiles

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 670
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     triple-layered microparticles comprising poly(d,l-lactide-co-glycolide, 50:50) (plga), poly(l-lactide) (plla) and poly(ethylene-co-vinyl acetate, 40 wt.% vinyl acetate) (eva) were fabricated using a one-step solvent evaporation technique, with ibuprofen drug localized in the eva core. the aim of this study was to investigate the drug release profiles of these triple-layered microparticles in comparison to double-layered (plla/eva and plga/eva) (shell/core) and single-layered eva microparticles. double- and triple-layered microparticles were shown to eliminate burst release otherwise observed for single-layered microparticles. for triple-layered microparticles, the migration of acidic pga oligomers from the plga shell accelerated the degradation of the plla mid-layer and subsequently enhanced drug release in comparison to double-layered plla/eva microparticles. further studies showed that drug release rates can be altered by changing the layer thicknesses of the triple-layered microparticles, and through specific tailoring of layer thicknesses, a zero-order release can be achieved. this study therefore provides important mechanistic insights into how the distinctive structural attributes of triple-layered microparticles can be tuned to control the drug release profiles.

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