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آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • pdmsstar–peg hydrogels prepared via solvent-induced phase separation (sips) and their potential utility as tissue engineering scaffolds

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    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 717
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    • شماره تماس دبیرخانه رویداد: -
     inorganic–organic hydrogels based on methacrylated star polydimethylsiloxane (pdmsstar-ma) and diacrylated poly(ethylene glycol) (peg-da) macromers were prepared via solvent-induced phase separation (sips). the macromers were combined in a dichloromethane precursor solution and sequentially photopolymerized, dried and hydrated. the chemical and physical properties of the hydrogels were further tailored by varying the number average molecular weight (mn) of peg-da (mn = 3.4k and 6k g mol−1) as well as the weight percent ratio of pdmsstar-ma (mn = 7k g mol−1) to peg-da from 0:100 to 20:80. compared to analogous hydrogels fabricated from aqueous precursor solutions, sips produced hydrogels with a macroporous morphology, a more even distribution of pdmsstar-ma, increased modulus and enhanced degradation rates. the morphology, swelling ratio, mechanical properties, bioactivity, non-specific protein adhesion, controlled introduction of cell adhesion, and cytocompatibility of the hydrogels were characterized. as a result of their tunable properties, this library of hydrogels is useful to study material-guided cell behavior and ultimate tissue regeneration.

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