مقاله Biomimetic poly(lactide) based fibrous scaffolds for ligament tissue engineering : تی پی بین

خلاصه مقاله

The aim of this study was to fabricate a fibrous scaffold that closely resembled the micro-structural architecture and mechanical properties of collagen fibres found in the anterior cruciate ligament (ACL). To achieve this aim, fibrous scaffolds were made by electrospinning l-lactide based polymers. l-Lactide was chosen primarily due to its demonstrated biocompatibility, biodegradability and high modulus. The electrospun fibres were collected in tension on a rotating wire mandrel. Upon treating these fibres in a heated aqueous environment, they possessed a crimp-like pattern having a wavelength and amplitude similar to that of native ACL collagen. Of the polymer fibre scaffolds studied, those made from poly(l-lactide-co-d,l-lactide) PLDLA exhibited the highest modulus and were also the most resilient to in vitro hydrolytic degradation, undergoing a slight decrease in modulus compared to the other polymeric fibres over a 6 month period. Bovine fibroblasts seeded on the wavy, crimp-like PLDLA fibres attached, proliferated and deposited extracellular matrix (ECM) molecules on the surface of the fibrous scaffold. In addition, the deposited ECM exhibited bundle formation that resembled the fascicles found in native ACL. These findings demonstrate the importance of replicating the geometric microenvironment in developing effective tissue engineering scaffolds.

نویسندگان

Denver C. Surrao [ Department of Chemical Engineering, Queen’s University, Kingston, ON, Canada ]

Stephen D. Waldman [ Department of Chemical Engineering, Queen’s University, Kingston, ON, Canada ]

Brian G. Amsden [ Department of Chemical Engineering, Queen’s University, Kingston, ON, Canada ]

کلمات کلیدی

Poly(lactide) Electrospinning Crimp like Collagen Fascicles

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Acta Biomaterialia

Acta Biomaterialia is an international journal that publishes peer-reviewed original research reports, review papers and communications in the broadly defined field of biomaterials science. The emphasis of the journal is on the relationship between biomaterial structure and function at all length scales. The journal is committed to rapid peer-review and publication.

حوزه های تحت پوشش : biomaterials science