محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال
حوزه های تحت پوشش رویداد

  • silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: characterization and cell response

    نویسندگان :
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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 720
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     α-tricalcium phosphate (α-tcp) is widely used as a reactant in calcium phosphate cements. this work aims at doping α-tcp with silicon with a twofold objective. on the one hand, to study the effect of si addition on the stability and reactivity of this polymorph. on the other, to develop si-doped cements and to evaluate the effect of si on their in vitro cell response. for this purpose a calcium-deficient hydroxyapatite was sintered at 1250 °c with different amounts of silicon oxide. the high temperature polymorph α-tcp was stabilized by the presence of silicon, which inhibited reversion of the β → α transformation, whereas in the si-free sample α-tcp completely reverted to the β-polymorph. however, the β–α transformation temperature was not affected by the presence of si. si–α-tcp and its si-free counterpart were used as reactants for a calcium phosphate cement. while si–α-tcp showed faster hydrolysis to calcium-deficient hydroxyapatite, upon complete reaction the crystalline phases, morphology and mechanical properties of both cements were similar. an in vitro cell culture study, in which osteoblast-like cells were exposed to the ions released by both materials, showed a delay in cell proliferation in both cases and stimulation of cell differentiation, more marked for the si-containing cement. these results can be attributed to strong modification of the ionic concentrations in the culture medium by both materials. ca-depletion from the medium was observed for both cements, whereas continuous si release was detected for the si-containing cement.

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