• polymer-coated mesoporous silica nanoparticles for the controlled release of macromolecules

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 609
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    • شماره تماس دبیرخانه رویداد: -
     with the goal of achieving constant release of large biological molecules over an extended period of time we focused on hybrid inorganic/organic nanoparticles. we synthesized poly(ethylene glycol) (peg)-coated mesoporous silica nanoparticles (msns) with incorporated trypsin inhibitor (ti), a model protein molecule for growth factors. due to the goal of incorporating large protein molecules the pore size of the as-synthesized msns was expanded by a hydrothermal treatment prior to ti incorporation. in vitro release from the msns without the thin polymer film shows an initial burst followed by continuous release. in the case of polymer-coated msns the initial burst release was completely suppressed and approximate zero order release was achieved for 4 weeks.

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