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نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال
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  • oral bioavailability of silymarin formulated as a novel 3-day delivery system based on porous silica nanoparticles

    نویسندگان :
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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 684
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the purpose of this study was to develop porous silica nanoparticles (psns) as a carrier to improve oral bioavailability of poorly water-soluble drugs, using silymarin as a model. psns were synthesized by reverse microemulsion and ultrasonic corrosion methods. a 3-day release formulation consisting of a silymarin solid dispersion, a hydrophilic gel matrix and silymarin-loaded psns was prepared. in vitro release studies indicated that both the silymarin-loaded psns and the 3-day release formulation showed a typical sustained-release pattern over a long period, about 72 h. the in vivo studies revealed that the 3-day release formulation gave a significantly higher plasma concentration and larger area under the concentration–time curves than commercial tablets when orally administered to beagle dogs. this implies that the prepared 3-day release formulation significantly enhanced the oral bioavailability of silymarin, suggesting that psns can be used as promising drug carriers for oral sustained release systems. thus providing a technically feasible approach for improving the oral bioavailability and long-term efficacy of poorly soluble drugs.

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