• semi-interpenetrating network of polyethylene glycol and photocrosslinkable chitosan as an in-situ-forming nerve adhesive

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 590
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     an ideal adhesive for anastomosis of severed peripheral nerves should tolerate strains imposed on rejoined nerves. we use blends of photocrosslinkable 4-azidobenzoic acid-modified chitosan (az-c) and polyethylene glycol (peg) as a new in-situ-forming bioadhesive for anastomosing and stabilizing the injured nerves. cryo-scanning electron microscopy suggests that the polymer blends form a semi-interpenetrating network (semi-ipn), where peg interpenetrates the az-c network and reinforces it. az-c/peg semi-ipn gels have higher storage moduli than az-c gel alone and fibrin glue. nerves anastomosed with an az-c/peg gel tolerate a higher force than those with fibrin glue prior to failure. a series of ex vivo and in vitro cell experiments indicate the az-c/peg gels are compatible with nerve tissues and cells. in addition, az-c/peg gels release peg over a prolonged period, providing sustained delivery of peg, a potential aid for nerve cell preservation through membrane fusion. az-c/peg semi-ipn gels are promising bioadhesives for repairing severed peripheral nerves not only because of their improved mechanical properties but also because of their therapeutic potential and tissue compatibility.

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