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آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • a complex of cyclohexane-1,2-diaminoplatinum with an amphiphilic biodegradable polymer with pendant carboxyl groups

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    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 673
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     a biodegradable and amphiphilic copolymer, mpeg-b-p(la-co-mcc), which contains pendant carboxyl groups, was chosen as a drug carrier for the active anticancer part (dach-pt) of oxaliplatin to form an mpeg-b-p(la-co-mcc/pt) complex. it was able to self-assemble into micelles with a mean diameter of 30–40 nm, and a surface potential near -10 mv. the typical platinum content was 10 wt.%. the micelles showed acid-responsive drug release kinetics, which is beneficial for drug release in the intracellular environment. the pt(ii) species were released mainly in the form of dach-pt-cl2 in 150 mm nacl solution and dach-pt2+-(h2o)2 in pure water according to the results obtained by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry and x-ray photoelectron spectroscopy. in vitro evaluation showed that the micelles displayed the same or higher cytotoxicities against skov-3, hela, and ec-109 cancer cells compared with oxaliplatin. the enhanced cytotoxicity against skov-3 cells is attributed to effective internalization of the micelles by the cells via endocytosis and the sensitivity of skov-3 cells to platinum drugs. this novel biodegradable and amphiphilic copolymer-based platinum drug will have great potential application in clinical use.

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