محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
اینستاگرام تی پی بین
حوزه های تحت پوشش رویداد

  • a naturally derived cardiac extracellular matrix enhances cardiac progenitor cell behavior in vitro

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 673
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     myocardial infarction (mi) produces a collagen scar, altering the local microenvironment and impeding cardiac function. cell therapy is a promising therapeutic option to replace the billions of myocytes lost following mi. despite early successes, chronic function remains impaired and is likely a result of poor cellular retention, proliferation, and differentiation/maturation. while some efforts to deliver cells with scaffolds have attempted to address these shortcomings, they lack the natural cues required for optimal cell function. the goal of this study was to determine whether a naturally derived cardiac extracellular matrix (cecm) could enhance cardiac progenitor cell (cpc) function in vitro. cpcs were isolated via magnetic sorting of c-kit+ cells and were grown on plates coated with either cecm or collagen i (col). our results show an increase in early cardiomyocyte markers on cecm compared with col, as well as corresponding protein expression at a later time. cpcs show stronger serum-induced proliferation on cecm compared with col, as well as increased resistance to apoptosis following serum starvation. finally, a microfluidic adhesion assay demonstrated stronger adhesion of cpcs to cecm compared with col. these data suggest that cecm may be optimal for cpc therapeutic delivery, as well as providing potential mechanisms to overcome the shortcomings of naked cell therapy.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها