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  • enhancement of lipopeptides production in a two-temperature-stage process under ssf conditions and its bioprocess in the fermenter

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1390/01/01
    • تاریخ انتشار در تی پی بین: 1390/01/01
    • تعداد بازدید: 720
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     a two-temperature-stage process was developed for the production of lipopeptides under ssf conditions. the effects of various temperatures, ranging from 25 to 40 °c, on the bacterial growth during the growth stage and on the production of lipopeptides during the productive stage were investigated. the optimum temperatures were found to be 30 °c for the growth of the strain and 37 °c for the biosynthesis of lipopeptides. the two-stage fermentation temperatures should be 30 °c in the initial 24 h and then 37 °c for the enhanced production of lipopeptides. the bioprocess results obtained in a 50 l fermenter verified the efficacy of this technique, which increased the yield of lipopeptides by 8.40% in flasks and by 13.11% in the fermenter, with a 4 h decrease of fermentation time in the fermenter. the 1000-fold scale-up of fermentation in a fermenter was successfully achieved.

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