مقاله Stress distributions and material properties determined in articular cartilage from MRI-based finite strains : تی پی بین

خلاصه مقاله

The noninvasive measurement of finite strains in biomaterials and tissues by magnetic resonance imaging (MRI) enables mathematical estimates of stress distributions and material properties. Such methods allow for non-contact and patient-specific modeling in a manner not possible with traditional mechanical testing or finite element techniques. Here, we employed three constitutive (i.e. linear Hookean, and nonlinear Neo-Hookean and Mooney–Rivlin) relations with known loading conditions and MRI-based finite strains to estimate stress patterns and material properties in the articular cartilage of tibiofemoral joints. Displacement-encoded MRI was used to determine two-dimensional finite strains in juvenile porcine joints, and an iterative technique estimated stress distributions and material properties with defined constitutive relations. Stress distributions were consistent across all relations, although the stress magnitudes varied. Material properties for femoral and tibial cartilage were found to be consistent with those reported in literature. Further, the stress estimates from Hookean and Neo-Hookean, but not Mooney-Rivlin, relations agreed with finite element-based simulations. A nonlinear Neo-Hookean relation provided the most appropriate model for the characterization of complex and spatially dependent stresses using two-dimensional MRI-based finite strain. These results demonstrate the feasibility of a new and computationally efficient technique incorporating MRI-based deformation with mathematical modeling to non-invasively evaluate the mechanical behavior of biological tissues and materials.

نویسندگان

Kent D. Butz [ School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA ]

Deva D. Chan [ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA ]

Eric A. Nauman [ School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA ]

Corey P. Neu [ Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA ]

کلمات کلیدی

Displacement encoded MRI Stress distributions Hyperelastic/nonlinear elasticity Finite strain Articular cartilage

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journal Of Biomechanics

Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical and experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership.

حوزه های تحت پوشش : مهندسی مکانیک، علوم فیزیک، علوم ریاضی