• the turnover of mineralized growth plate cartilage into bone may be regulated by osteocytes

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1390/06/01
    • تاریخ انتشار در تی پی بین: 1390/06/01
    • تعداد بازدید: 344
    • تعداد پرسش و پاسخ ها: 0
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    during endochondral ossification, growth plate cartilage is replaced with bone. mineralized cartilage matrix is resorbed by osteoclasts, and new bone tissue is formed by osteoblasts. as mineralized cartilage does not contain any cells, it is unclear how this process is regulated. we hypothesize that, in analogy with bone remodeling, osteoclast and osteoblast activity are regulated by osteocytes, in response to mechanical loading. since the cartilage does not contain osteocytes, this means that cartilage turnover during endochondral ossification would be regulated by the adjacent bone tissue. we investigated this hypothesis with an established computational bone adaptation model. in this model, osteocytes stimulate osteoblastic bone formation in response to the mechanical bone tissue loading. osteoclasts resorb bone near randomly occurring microcracks that are assumed to block osteocyte signals. we used finite element modeling to evaluate our hypothesis in a 2d-domain representing part of the growth plate and adjacent bone. cartilage was added at a constant physiological rate to simulate growth. simulations showed that osteocyte signals from neighboring bone were sufficient for successful cartilage turnover, since equilibrium between cartilage remodeling and growth was obtained. furthermore, there was good agreement between simulated bone structures and rat tibia histology, and the development of the trabecular architecture resembled that of infant long bones. additionally, prohibiting osteoclast invasion resulted in thickened mineralized cartilage, similar to observations in a knock-out mouse model. we therefore conclude that it is well possible that osteocytes regulate the turnover of mineralized growth plate cartilage.

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