مقاله Muscle extracellular matrix applies a transverse stress on fibers with axial strain : تی پی بین

خلاصه مقاله

It is widely assumed that skeletal muscle contraction is isovolumic. This assumption has been verified at the single fiber and at the myofibril level. Model development and mechanical analyses often exploit this assumption when investigating skeletal muscle and evaluating muscle mechanical properties. This communication describes a method whereby individual muscle fibers and bundles of fibers, which include their constituent extracellular matrix (ECM), were tested to define the change in volume with axial strain. The results demonstrate that fibers are isovolumic, but bundles decrease in volume with strain. The loss of volume implicates a transverse force being applied to the fibers by the ECM. The nature and importance of this transverse force warrant further investigation.

نویسندگان

Lucas R. Smith [ Department of Bioengineering, University of California, San Diego, USA ]

Lewis Gerace-Fowler [ Department of Orthopaedic Surgery 0863, University of California, UC San Diego and VA Medical Center, 9500 Gilman Drive, Mail Code 0863, La Jolla, CA 92093-0863, USA ]

Richard L. Lieber [ Department of Orthopaedic Surgery 0863, University of California, UC San Diego and VA Medical Center, 9500 Gilman Drive, Mail Code 0863, La Jolla, CA 92093-0863, USA ]

کلمات کلیدی

Muscle Extracellular matrix Isovolumic

آدرس این مقاله

آدرس مستقیم دسترسی به این مقاله

مشخصات کنفرانس

مشاهده مقالات

journal Of Biomechanics

Journal of Biomechanics publishes reports of original and substantial findings using the principles of mechanics to explore biological problems. Analytical and experimental papers may be submitted, and the journal accepts original articles, surveys and perspective articles (usually by Editorial invitation only), book reviews and letters to the Editor. The criteria for acceptance of manuscripts include excellence, novelty, significance, clarity, conciseness and interest to the readership.

حوزه های تحت پوشش : مهندسی مکانیک، علوم فیزیک، علوم ریاضی