• loading imatinib on to zein nanoparticles and checking its release by ph-dependent

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    • تاریخ ارائه: 1396/07/16
    • تاریخ انتشار در تی پی بین: 1396/07/16
    • تعداد بازدید: 360
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -

    over the past three decades, there has been a considerable research interest in the area of developing drug delivery using nanoparticles (nps) as carriers for small and large molecules. targeting delivery of drugs to the diseased lesions is one of the most important aspects of drug delivery system. zein-based delivery systems have been particularly investigated for hydrophobic drugs and nutrients. recently, increasing attention has been drawn to fabricate zein-based advanced drug delivery systems for various applications. imatinib (imt) is a cancer medication prescribed to is used to treat certain types of leukemia and other cancers and disorders of the blood cells. (imt) is in a class of medications called kinase inhibitors. this study proposes a new zein nanoparticle (zp) encapsulated imatinab (im). the drug release to be examined by changing ph. the zps were prepared by phase separation process. in vitro drug release to be examined in ph 2 and ph 7.4 zein was dissolved in a concentration of 10 mg / ml in ethanol 78%. the crystal size of the zein nanoparticles is calculated by the sherer's method by xrd. the drug is loaded into nanoparticles and using the dialysis method, it is released in an acidic environment (the environment close to the cancer cell) and the base environment (the natural environment of the body).

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