investigation of antibacterial activity and synthesis of zirconia meso-porous nanoparticles by soft molding

daily increase of antimicrobial resistance in microorganisms is a major concern for human health. this requires the search for new unconventional antimicrobial agents. nano-material technology, makes us hopeful to fight infectious diseases by using nanoparticles with antimicrobial activity. among various metal oxides, zro₂ is used in various implant devices due to its good mechanical properties and biocompatibility. as a ceramic, zro₂ has several advantages such as corrosion resistance, mechanical strength, abrasion resistance, fracture toughness and chemical stability. in this paper, the evaporation-induced self-assembly (eisa) method is used for synthesis meso-porous zirconia. in addition, pluronic f127 is applied to achieve a greater surface area. the results show that aging and calcination temperature are effective parameters to increase the specific surface area and pore size reduction. various analyzes such as xrd, tem and absorption/desorption analysis of nitrogen was carried out in order to determine the specific surface area, pore size and volume, phase structure and morphology of the synthesized meso-porous material. it was observed that there is a high surface area of about 184.66 m²g^-1 with pore size of 3.05 nm at calcination temperature of 400°c. agar diffusion method was used to investigate the antibacterial activity of zirconia meso-porous nanoparticles. in this method, the gram-positive (s.aureus) and gram-negative (e.coli) bacteria were used, according to their clinical significance, and it was found that zirconia meso-porous nanoparticles have a high antimicrobial activity against s.aureus bacteria relative to e. coli bacteria.