development of gelatin microsphere encapsulated cu-based metal-organic framework for methotrexate delivery

the purpose of the study is to the effective approach for the development of methotrexate (mtx) loaded as an anticancer drug into cu-based metal-organic framework nanohybrid (cu-mof/mtx) inserted in ph-sensitive gelatin microsphere biopolymer (cu-mof/mtx@gm). mtx was loaded into two-dimensional tunnels and the empty face-centered cubic lattice of cu-mof porous. the developed cu-mof/mtx@gm was characterized using sem, xrd, and ftir analysis. in vitro drug release was revealed through the comparison of the simulated physiological conditions and tumor tissue environment for showing the mtx release ability of the obtained novel microspheres. according to the obtained results, the developed carrier has promising qualities as an excellent candidate for target delivery of mtx to cancer tissues.