• carbohydrate quantity and quality affect the risk of endometrial cancer: a systematic review and dose-response meta-analysis

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    • تاریخ ارائه: 1398/06/20
    • تاریخ انتشار در تی پی بین: 1398/06/20
    • تعداد بازدید: 229
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    carbohydrate quantity and quality affect the risk of endometrial cancer: a systematic review and dose-response meta-analysis

    objective: data on the association of glycemic index (gi) and glycemic load (gl) with risk of endometrial cancer up to 2012 have been summarized in a meta-analysis.

    methods: the online databases were searched for relevant publications up to may 2018. overall, 8 prospective cohort and 5 case-control studies were included in the systematic review and meta-analysis. two reviewers independently screened literature according to the inclusion and exclusion criteria. results: subgroup analysis revealed a significant positive association between dietary intake of total carbohydrate and risk of endometrial cancer after combining estimates from 3 prospective cohort studies with ≥10 years’ duration of follow-up (combined effect size: 1.29, 95% ci: 1.09-1.53, p = 0.003) and when 3 prospective cohort studies with sample size of ≥50,000 participants were combined (combined effect size: 1.24, 95% ci: 1.08-1.43, p = 0.002). in addition, a non-linear dose-response relationship was found in this regard after considering estimates from prospective cohort studies (pnonlinearity = 0.002). combining effect sizes from case-control studies showed a significant positive association between gi and risk of endometrial cancer; such that in linear dose-response analysis, a 10 unit increase in gi was associated with 4% greater risk of endometrial cancer. however, this association was not significant in prospective cohort studies (p>0.50).conclusions: although dietary intake of total carbohydrate, gi and gl were not significantly associated with risk of developing endometrial cancer, we did find positive association in some subgroups. we found a significant positive non-linear association of gi and gl with risk of endometrial cancer.

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