• inhibition of mir-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting reck

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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    • شماره تماس دبیرخانه رویداد: -
     micrornas play critical roles in the progression and metastasis of nonsmall cell lung cancer (nsclc). mir-92b acts as an oncogene in some malignancies; however, its role in nsclc remains poorly understood. here, we found that mir-92b was significantly increased in human nsclc tissues and cell lines. inhibition of mir-92b remarkably suppressed cell proliferation, migration, and invasion of nsclc cells. reversion-inducing-cysteine-rich protein with kazal motifs (reck) was identified to be a target of mir-92b. expression of mir-92b was negatively correlated with reck in nsclc tissues. collectively, mir-92b might promote nsclc cell growth and motility partially by inhibiting reck.

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