محبوبترین نویسندگان :
نویسندگان مقالات پربازدید :
مجله رفتار مکانیکی مواد زیست پزشکی
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال

  • investigation of the material properties of alginate for the development of hydrogel repair of dura mater

    نویسندگان :
    کلمات کلیدی :
    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1394/01/01
    • تاریخ انتشار در تی پی بین: 1394/01/01
    • تعداد بازدید: 1004
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     the collagenous dura mater isolates the brain from the external environment and requires a secure closure following invasive neurosurgery. this is typically accomplished by approximation of the dura mater via sutures and adhesives. in selected cases, however, large portions of dura mater require excision, necessitating a tissue replacement patch. the mild reaction conditions and long-term biocompatibility of alginate evince strong candidacy for these applications. this study investigates the potential of diffusion and internally gelled alginates for these applications. specifically, we quantified the viscosity, gel rate, syneresis level, compressive strength, compressive modulus, complex modulus and loss angle in the context of dura mater repair. the ideal sealant would have a rapid cross-link speed, while the ideal dura mater replacement would have a low level of syneresis. both applications require a compressive modulus of 20–100 kpa and a complex modulus of 1–24 kpa. the data collected in this study suggests that the use of 1.95 wt% 43 mpa s alginate with 200 mm cacl2 is sufficient for approximating the dural membrane for closure alone or in conjunction with suture. alternatively, the use of 1.95 wt% 43 mpa s alginate with 100 mm caco3 is sufficient for tissue replacement in large dural defects.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین رویدادها
مقالات جدیدترین ژورنال ها