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نویسندگان مقالات پربازدید :
مواد زیستی
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1391/01/01
    • تاریخ انتشار در تی پی بین: 1391/01/01
    • تعداد بازدید: 615
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     photodynamic therapy (pdt) has emerged as a treatment for certain malignant-like skin, head and neck, gastrointestinal, and gynecological cancers. the broader acceptance of pdt treatment for large or deep-seated tumors is still hindered, at least in part, by the low photodynamic efficiency of photosensitizers (ps) in the deep-seated tumor environment where the light energy fluency rate is severely attenuated after propagation via skin and/or tissue barriers. in this report, efficient nuclear-targeted intracellular delivery of ps is achieved using an easily fabricated yet entirely biocompatible and inexpensive polysaccharide-functionalized nanoscale lipid carrier, which triggers the intracellular release of photosensitizers inside cancer cells and targets cell nuclear to achieve a significantly enhanced photocytotoxicity. cancer cells are killed efficiently even under an extremely low light fluency of 1 mw/cm2 attenuated via an interval meat layer with a thickness of 3 mm. therefore, this nuclei-targeting system may contribute to the development of a new generation of ps carriers that fight against deep-seated tumors and that exhibit excellent photodynamic efficiency under faint light irradiation.

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