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نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 710
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     stromal cell-derived factor 1 (sdf-1) is an important chemokine in stem cell mobilization, and plays a critical role in the biological and physiological functions of mesenchymal stem cells (msc). however, the use of sdf-1 in tissue regeneration is limited by two drawbacks, which are its short half-life and ready degradation by enzymes. this study investigates the release of sdf-1 from chitosan-based nanoparticles (np) and evaluates the effect of released sdf-1 on the migration of msc. among the prepared chitosan-based np a chitosan/tripolyphosphate/fucoidan (cs/tpp/f) np is the most effective carrier for sdf-1 release. cs/tpp/f np are spherical and effectively encapsulate sdf-1. the cs/tpp/f np protected sdf-1 against proteolysis and heat treatment and controlled its release for up to 7 days. the concentration of released sdf-1 reached 23 ng ml−1. according to in vitro experiments on cells the released sdf-1 retained its mitogenic activity, promoted the migration of msc and enhanced pi3k expression. biocompatible cs/tpp/f np may be effective as carriers for the delivery and controlled release of sdf-1 to mobilize stem cells in tissue engineering applications.

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