In this paper, artificial neural network (ANN) and genetic algorithm (GA) were applied to observe the optimal practical conditions, i.e., adsorbent dosage, sonication time, MB concentration, Auramine-O (AO) concentrations, Er concentration as input parameters and % removal AO as output parameters. To enhance the adsorption of AO dye from ternary aqueous solutions containing AO, Erythrosine (Er) and Methylene Blue (MB) were rapidly performed onto the copper-doped zinc sulfide nanoparticles loaded...