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ژنتیک
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • comparison of early and mid-trimester amniocentesis in 1459 amniotic fluid cultures

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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    • شماره تماس دبیرخانه رویداد: -
     early amniocentesis is a new context in prenatal diagnosis. however, the consequences of this procedure are not known clearly. we compared cytogenetic results of 655 amniotic fluid samples obtained at 12-14 gestational weeks (early amniocentesis, ea) and 804 samples at 15-18 gestational weeks (mid-trimester amniocentesis, ma). the rate of chromosomal abnormalities for early amniocentesis was 3.2% (21 cases) and for mid-trimester amniocentesis was 5.3% (43 cases) (p=0.047). true mosaicism was seen in 2 cases mt group (p=1.000). we did not have maternal cell contamination in either group. the ratio of repeat amniocentesis was 0.6 percent in the ea group compared with 0.2 percent in ma group (p=0.417).  procedure-related early abortion (within the first 30 days after amniocentesis) was seen in 4 cases of ea (2.2%) and 3 cases of ma (1.5%) (p=0.719). hemorrhage occured in the same ratio. intra-uterine fetal death (iufd) was seen in 7 cases of ma, but not in any cases of ea (p=0.015). our findings showed comparable outcome in two method of amniocentesis, except for lower chromosomal abortion rate and iufd.

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