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نویسندگان مقالات پربازدید :
آکتا بیومتریال
جزئیات رویداد
اینستاگرام تی پی بین
همایش ، رویداد ، ژورنال
حوزه های تحت پوشش رویداد

  • growth factor supplementation improves native and engineered meniscus repair in vitro

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/01/01
    • تاریخ انتشار در تی پی بین: 1392/01/01
    • تعداد بازدید: 580
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     few therapeutic options exist for meniscus repair after injury. local delivery of growth factors may stimulate repair and create a favorable environment for engineered replacement materials. in this study we assessed the effect of basic fibroblast growth factor (bfgf) (a pro-mitotic agent) and transforming growth factor β3 (tgf-β3) (a pro-matrix formation agent) on meniscus repair and the integration/maturation of electrospun poly(ε-caprolactone) (pcl) scaffolds for meniscus tissue engineering. circular meniscus repair constructs were formed and refilled with either native tissue or scaffolds. repair constructs were cultured in serum-containing medium for 4 and 8 weeks with various growth factor formulations, and assessed for mechanical strength, biochemical content, and histological appearance. results showed that either short-term delivery of bfgf or sustained delivery of tgf-β3 increased integration strength for both juvenile and adult bovine tissue, with similar findings for engineered materials. while tgf-β3 increased proteoglycan content in the explants, bfgf did not increase dna content after 8 weeks of culture. this work suggests that in vivo delivery of bfgf or tgf-β3 may stimulate meniscus repair, but that the time course of delivery will strongly influence success. further, this study demonstrates that electrospun scaffolds are a promising material for meniscus tissue engineering, achieving comparable or superior integration compared with native tissue.

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