همایش ، رویداد ، ژورنال
اینستاگرام تی پی بین
حوزه های تحت پوشش رویداد
  • synthesis of polyethyleneimine-stabilized gold nanoparticles for colorimetric sensing of heparin

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 1039
    • تعداد پرسش و پاسخ ها: 0
    • شماره تماس دبیرخانه رویداد: -
     heparin is widely used as an anticoagulant/antithrombotic agent during clinical procedures. overdosing of heparin can induce significant detrimental effects, such as hemorrhages and thrombocytopenia; therefore, measurement of heparin level in serum during therapy period or within infusion solutions is of vital importance. in this work, we demonstrate a green synthesis of polyethyleneimine (pei)-stabilized gold nanoparticles (pei/aunps) for highly selective and sensitive colorimetric sensing of heparin. by simply mixing pei and au salt in aqueous solution at room temperature, aunps with a mean diameter of 4.4 nm can be easily formed. the formed positively charged pei/aunps are able to interact with the negatively charged heparin via electrostatic interaction, resulting in the aggregation of aunps accompanied by a color change from wine red to light blue in solution. the color change reflected by the variation of the relevant spectroscopic features of aunps allows us to establish a simple, visual, and quantitative approach for colorimetric sensing of heparin. we show that the prepared pei/aunps are able to detect the concentration of heparin within a range of 3–11 μg/ml, and the method has a high sensitivity with a heparin detection limit of 1.5 μg/ml and excellent selectivity in the presence of other biopolymers and small molecules.

سوال خود را در مورد این مقاله مطرح نمایید :

با انتخاب دکمه ثبت پرسش، موافقت خود را با قوانین انتشار محتوا در وبسایت تی پی بین اعلام می کنم
مقالات جدیدترین ژورنال ها