• exosomes from human adipose-derived mesenchymal stem cells promote migration through wnt signaling pathway in a breast cancer cell model

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    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
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     human mesenchymal stem cell (msc)-conditioned medium (cm) was previously reported to affect the biology of tumor cells; however, the precise mechanisms remain unclear. here, we show that mscs secreted 40–100 nm particles, which have the typical characteristics of exosomes, and these msc-derived exosomes promoted migration of the breast cancer cell line mcf7. global gene expression profiling revealed that several cancer-related signaling pathways were upregulated after exosome treatment in mcf7, and the wnt signaling pathway was further confirmed to be activated. our findings demonstrated a new mechanism through which msc-cm may contribute to tumor cell migration.

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