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بیوشیمی مولکولی و سلولی 2013
جزئیات رویداد
همایش ، رویداد ، ژورنال
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  • ifn-γ (+874) and not tnf-α (−308) is associated with hbv-hcc risk in india

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    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 868
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    • شماره تماس دبیرخانه رویداد: -
     tumor necrosis factor (tnf)-α and interferon (ifn)-γ, the pro-inflammatory th1 cytokines are the indispensable coordinators of the inflammatory responses involved in hepatitis b virus (hbv) pathogenesis. this study attempted to evaluate any possible association among tnf-α (−308g>a) and ifn-γ (+874t/a) genotypes, the spontaneous blood and mrna levels and expression of their major signal transducers, namely stat1 and nf-кb with hepatitis b virus-induced hepatocellular carcinoma (hcc) susceptibility in india. for this, 398 subjects (146 controls, 68 inactive-hbv-carriers, 64 chronic-active hbv patients, 61 hbv-cirrhotics, and 59 hbv-hcc subjects) were enrolled. polymerase chain reaction–restriction fragment length polymorphism, allele-specific pcr, enzyme-linked immunosorbent assay, reverse transcriptase-pcr, and western blot analysis were done for assessing polymorphism, blood levels, mrna expression, and protein expression of signal transducers, respectively, of tnf-α and ifn-γ. the study revealed no significant association of tnf-α (−308) ga genotype, while a significant negative association of ifn-γ (+874) ta and aa genotypes, in hbv-hcc risk. moreover, blood levels of tnf-α were significantly elevated as disease progresses to hcc, while ifn-γ levels were raised in hcc patients only. besides, ifn-γ mrna levels were significantly elevated in cirrhotics, with no change observed in tnf-α transcript levels. moreover, nf-кb expression also consistently increased during hcc progression. these observations suggest a vital negative association of ifn-γ (+874) with hbv-hcc risk, with no significant association evident in tnf-α (−308). however, the tnf-α and ifn-γ levels markedly increased in hcc development.

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