• mir-25 promotes gastric cancer cells growth and motility by targeting reck

    جزئیات بیشتر مقاله
    • تاریخ ارائه: 1392/07/24
    • تاریخ انتشار در تی پی بین: 1392/07/24
    • تعداد بازدید: 953
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    • شماره تماس دبیرخانه رویداد: -
     gastric cancer (gc) is the second leading cause of cancer-related death worldwide. recently, accumulating evidence suggests that micrornas (mirnas) play prominent roles in tumorigenesis and metastasis. here, we confirmed that mir-25 was significantly increased in human gc tissues and cell lines. forced expression of mir-25 remarkably enhanced cell proliferation, migration, and invasion in gc cells, whereas inhibition of mir-25 by inhibitor caused significant suppression of proliferation and significant increase of apoptosis. moreover, inhibition of mir-25 significantly decreased migration and invasion of gc cells. finally, reversion-inducing-cysteine-rich protein with kazal motifs (reck) was found to be a target of mir-25. overexpression of reck could significantly reverse the oncogenic effect of mir-25. taken together, mir-25 might promote gc cells growth and motility partially by targeting reck.

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